Unintegrated viral DNA sequences in a hamster tumor induced by bovine papilloma virus
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Unintegrated viral DNA sequences in a hamster tumor induced by bovine papilloma virus.
A fibrosarcoma was induced in a hamster by bovine papilloma virus type 2 (BPV2). The content of BPV2 DNA sequences was measured by DNA-DNA and cRNA-DNA hybridizations. The tumor contained approximately 300 BPV2 genome equivalents per cell. Southern blot hybridization indicated that the viral DNA was in free form, the entire genome most likely being present. In situ hybridization with BPV2 cRNA ...
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Bovine papilloma virus was injected s.c. and intracerebrally in newborn and weanling hamsters. Connective tissue tumors (fibromas, chondromas, and meningiomas) were produced in the subcutaneous regions of the back, pinna of the ear, and the meninges. The tumors did not contain evidence of viral infection when examined by histologie, immunofluorescent, and electron microscopic means. The tumors ...
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ژورنال
عنوان ژورنال: Journal of Virology
سال: 1981
ISSN: 0022-538X,1098-5514
DOI: 10.1128/jvi.39.3.945-949.1981